| Annotated protein: | Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (PP1bp175) (Protein phosphatase 1 regulatory subunit 9A) (p180). Gene symbol: PPP1R9A. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: O35867 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PPP1R9A |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic actin cytoskeleton (GO:0098871) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Zito K, et al. "Induction of spine growth and synapse formation by regulation of the spine actin cytoskeleton" Neuron. 2004 Oct 14;44(2):321-34 PMID:15473970 |
| Figure(s): | Fig.1 and 2 |
| Annotation description: | Neurabin-I is a known actin-binding protein (see Additional literature and others). Fig.1: GFP-NrbI Is Concentrated in Dendritic Spines Fig.2: Spine Localization of GFP-NrbI Requires the Intact Actin Cytoskeleton Together this shows that in the postsynapse neurabin is localized to the actin cytoskeleton (hippocampal neurons). |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Jan van Weering (ORCID:0000-0001-5259-4945) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | Title: "Neurabin: a novel neural tissue-specific actin filament-binding protein involved in neurite formation" @ PMID:9362513 |
| SynGO annotation ID: | 1709 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |