| Annotated protein: | Dynamin-1 (EC 3.6.5.5). Gene symbol: DNM1. Taxonomy: Mus musculus (Mouse). Uniprot ID: P39053 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ DNM1 |
| Ontology domain: | Cellular Component |
| SynGO term: | presynaptic endocytic zone membrane (GO:0098835) |
| Synapse type(s): | Photoreceptor ribbon synapse |
| Annotated paper: | Wahl S, et al. "A local, periactive zone endocytic machinery at photoreceptor synapses in close vicinity to synaptic ribbons" J Neurosci. 2013 Jun 19;33(25):10278-300 PMID:23785143 |
| Figure(s): | figure 2 and 4 |
| Annotation description: | The authors use light microscopy to localize dynamin in mouse photoreceptor cells. The protein is found in the synaptic layers of the retina in close proximity to the synaptic ribbon, the release site in these neurons. Figure 2 uses standard confocal microscopy. Figure 4 uses immunogold electron microscopy to localize dynamin at the synaptic plasma membrane in proximity to the synaptic ribbon. 15/11/2017 Pim - For PMID:23785143 I allow annotation to term 'presynaptic endocytic zone' because the authors claim this as an experimental finding. The title states "A local, periactive zone endocytic machinery at photoreceptor synapses in close vicinity to synaptic ribbons" |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy Confocal |
| Annotator(s): | Peter McPherson (ORCID:0000-0001-7806-5662) |
| Lab: | Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada |
| SynGO annotation ID: | 1704 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |