| Annotated protein: | Dynamin-1 (EC 3.6.5.5) (B-dynamin) (D100) (Dynamin, brain). Gene symbol: DNM1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P21575 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ DNM1 |
| Ontology domain: | Cellular Component |
| SynGO term: | presynaptic endocytic zone membrane (GO:0098835) |
| Synapse type(s): | brainstem |
| Annotated paper: | Takei K, et al. "Tubular membrane invaginations coated by dynamin rings are induced by GTP-gamma S in nerve terminals" Nature. 1995 Mar 9;374(6518):186-90 PMID:7877693 |
| Figure(s): | figure 2 |
| Annotation description: | The authors treat rat brain synaptosomes with GTPgammaS preventing the budding of clathrin coated vesicles. By EM (Figures 2c-j) dynamin is seen to coat the necks of the clathrin-coated pits. In figure 2a/b the author use conventional light microscopy to show dynamin 1 in presynaptic terminals. 17/11/2017 Pim - I have removed the 'extrinsic component of ...' element of the selected term because the mode of membrane interaction was not addressed in the presented data. |
| Evidence tracking, Biological System: | Intact tissue Cell-free system |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy Wide-field fluorescence |
| Annotator(s): | Peter McPherson (ORCID:0000-0001-7806-5662) |
| Lab: | Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada |
| SynGO annotation ID: | 1703 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |