Annotated protein:Dynamin-3 (EC 3.6.5.5). Gene symbol: DNM3. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8BZ98
antibody wiki:
SynGO gene info:SynGO data @ DNM3
Ontology domain:Cellular Component
SynGO term:presynapse (GO:0098793)
Synapse type(s):spinal cord
Annotated paper:Raimondi A, et al. "Overlapping role of dynamin isoforms in synaptic vesicle endocytosis" Neuron. 2011 Jun 23;70(6):1100-14 PMID:21689597
Figure(s):Figure 1
Annotation description:Figure 1A. The authors use validated dynamin 3 antibodies (figure 1E and supplemental figure 1) to localize dynamin 3 to the presynaptic nerve terminal. This is performed in mouse spinal cord (synapses on ventral horn motor neurons). The resolution of this figure is only sufficient to say presynaptic, but coupled with BP data from this paper covered under ticket 676 I assigned this GO to endocytic zone.
Evidence tracking, Biological System:Intact tissue
Evidence tracking, Protein Targeting:Antibody (detection)
Evidence tracking, Experiment Assay:Confocal
Annotator(s):Peter McPherson (ORCID:0000-0001-7806-5662)
Lab:Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada
SynGO annotation ID:1699
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology