| Annotated protein: | Disks large-associated protein 3 (DAP-3) (PSD-95/SAP90-binding protein 3) (SAP90/PSD-95-associated protein 3) (SAPAP3). Gene symbol: DLGAP3. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q6PFD5 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ DLGAP3 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic specialization (GO:0099572) |
| Synapse type(s): | spinal cord, glutamatergic brain, glutamatergic peripheral nervous system, acetylcholinergic Neuro-muscular junction |
| Annotated paper: | Welch JM, et al. "Differential mRNA expression and protein localization of the SAP90/PSD-95-associated proteins (SAPAPs) in the nervous system of the mouse" J Comp Neurol. 2004 Apr 19;472(1):24-39 PMID:15024750 |
| Figure(s): | fig 5; fig 8; fig.9; fig 11 |
| Annotation description: | Fig. 5 SAPAP3 is enriched in PSD fractions Literal: "We found that SAPAP1, -3, and -4 were all highly enriched in PSD fractions." Fig. 8 SAPAP3 is expressed at neuronal cholinergic synapses Literal "SAPAP 3 is highly enriched at synapses in the submandibular ganglion, as demonstrated by simultaneously staining the sections for the presynaptic marker protein synaptophysin (Fig. 8B,D,F). Fig 11 SAPAP3 proteins colocalize with PSD-95. Literal "SAPAP1, -3, and -4 all showed extensive colocalization with PSD-95 (Fig. 11), implying, as expected, that SAPAP1, -3, and -4 were located at glutamatergic synapses in the spinal cord. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal Western blot Biochemical fractionation (generic) |
| Annotator(s): | Chiara Verpelli (ORCID:0000-0003-2949-9725) Carlo Sala (ORCID:0000-0003-0662-9523) |
| Lab: | CNR Neuroscience Institute Milan and Dept. of Biotechnology and Translational Medicine, University of Milan, 20129 Milan, Italy |
| SynGO annotation ID: | 1697 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |