Di Paolo G, et al. "Decreased synaptic vesicle recycling efficiency and cognitive deficits in amphiphysin 1 knockout mice" Neuron. 2002 Feb 28;33(5):789-804 PMID:11879655
Figure(s):
figure 1D
Annotation description:
In figure 1D the authors use an antibody against amphiphysin to demonstrate that the protein is localized pre-synaptically in mouse cortical neurons in culture. The specificity of the antibody is shown by lack of staining in an amphiphysin knockout mouse. In the additional literature I cite a paper using electron microscopy in lamprey demonstrating that lamprey amphiphysin is found on membranes of the endocytic zone following stimulation.
Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada
Additional literature:
Using the lamprey giant synapse, the authors use electron microscopy to demonstrate that lamprey amphiphysin is found on membranes of the endocytic zone following stimulation (figure 5). @ PMID:15180828
