| Annotated protein: | VAMP-associated protein 33kDa, isoform A. Gene symbol: VAP33. Taxonomy: Drosophila melanogaster (Fruit fly). Uniprot ID: Q7KVX5 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ VAPA SynGO data @ VAPB |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of presynaptic membrane (GO:0099056) |
| Synapse type(s): | acetylcholinergic Neuro-muscular junction |
| Annotated paper: | Pennetta G, et al. "Drosophila VAP-33A directs bouton formation at neuromuscular junctions in a dosage-dependent manner" Neuron. 2002 Jul 18;35(2):291-306 PMID:12160747 |
| Figure(s): | Fig4 |
| Annotation description: | Fig4 shows immuno-EM against DVAP-33A in drosophila neuromuscular junction. The gold label can be found on the presynaptic plasma membrane (Fig4A-E) and large vesicles in the presynaptic terminal (Fig4F), the synaptic vesicles remain unstained (Fig4E). DVAP-33A has a transmembrane domain (Fig1C), hence it is likely it is an integral part of these membrane structures. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Jan van Weering (ORCID:0000-0001-5259-4945) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 1689 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |