| Annotated protein: | Chondroitin sulfate proteoglycan 5 (Acidic leucine-rich EGF-like domain-containing brain protein) (Neuroglycan C). Gene symbol: CSPG5. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q71M36 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CSPG5 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic membrane (GO:0099055) |
| Synapse type(s): | cerebellum, glutamatergic |
| Annotated paper: | Aono S, et al. "Genomic organization and expression pattern of mouse neuroglycan C in the cerebellar development" J Biol Chem. 2000 Jan 7;275(1):337-42 PMID:10617623 |
| Figure(s): | Fig. 8A |
| Annotation description: | Neuroglycan C immunoractivity is localized in Purkinje cell synapses of the five-day old cerebellum. "The cell membrane and the membranes of endoplasmic reticula were not immunostained in the other types of cell, such as granule cells and Bergmann glial cells.". p. 341 (statement of the authors). Accordingly, the protein must be postsynaptic. 24/11/2017 Pim - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| Additional literature: | Supplemental table S1 contains 698 synaptic proteins identified in three different experimental approaches: isolated PSD preparation, MAGUK-associated signalling complexes (MASC) and AMPA receptor complexes (ARCs). CSPG5 was found in the isolated PSD fraction. @ PMID:16635246 |
| SynGO annotation ID: | 1657 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |