| Annotated protein: | Cerebellin-1 (Brain protein D3) (Precerebellin) [Cleaved into: Cerebellin (CER); [des-Ser1]-cerebellin (des-Ser1-cerebellin)]. Gene symbol: CBLN1. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q9R171 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CBLN1 |
| Ontology domain: | Cellular Component |
| SynGO term: | synaptic cleft (GO:0043083) |
| Synapse type(s): | Parallel fibre (cerebellum -> Purkinje-cell) |
| Annotated paper: | Miura E, et al. "Cbln1 accumulates and colocalizes with Cbln3 and GluRdelta2 at parallel fiber-Purkinje cell synapses in the mouse cerebellum" Eur J Neurosci. 2009 Feb;29(4):693-706 PMID:19250438 |
| Figure(s): | Fig. 5F, 6 |
| Annotation description: | Fig. 5 F shows clearly the labeling of Cerebellin-1 at the parallel fibre-interneuron synapses. Fig. 6 quantifies the immunogold-localization. 17/11/2017 Pim - CBLN1_MOUSE, Precerebellin, Cerebellin-1 is a known secreted protein that has no TM domains or other known lipid-interacting domains. The localization at the synaptic junction is therefore reasonably assumed to be in the postsynaptic cleft. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| Additional literature: | Table S1 contains 452 proteins identified in PSD (detergent-resistant synaptic junctional proteins) preparations of rat and mouse brains. Precerebellin was found as "XP_194433 Similar to precerebellin-1". @ PMID:15169875 This paper shows that Cerebellin-1 supports synapse formation at parallel fibre synapses in the cerebellum and hippocampal synapses in culture. @ PMID:21410790 |
| SynGO annotation ID: | 1654 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |