Annotated protein:Alpha-internexin (Alpha-Inx) (66 kDa neurofilament protein) (NF-66) (Neurofilament-66). Gene symbol: INA. Taxonomy: Mus musculus (Mouse). Uniprot ID: P46660
antibody wiki:
SynGO gene info:SynGO data @ INA
Ontology domain:Cellular Component
SynGO term:postsynapse (GO:0098794)
Synapse type(s):striatum
neocortex
Annotated paper:Yuan A, et al. "Neurofilament subunits are integral components of synapses and modulate neurotransmission and behavior in vivo" Mol Psychiatry. 2015 Aug;20(8):986-94 PMID:25869803
Figure(s):Fig1, FigS2 and Fig2
Annotation description:Fig1 shows by quantitative immunoEM that α-internexin is mainly present in the postsynapse.
Evidence tracking, Biological System:Intact tissue
Evidence tracking, Protein Targeting:Antibody (detection)
Evidence tracking, Experiment Assay:Electron Microscopy
Annotator(s):Jan van Weering (ORCID:0000-0001-5259-4945)
Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:1652
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology