| Annotated protein: | Calbindin (Calbindin D28) (D-28K) (Spot 35 protein) (Vitamin D-dependent calcium-binding protein, avian-type). Gene symbol: CALB1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P07171 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CALB1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | cerebellum |
| Annotated paper: | Schmidt H, et al. "Calbindin D28k targets myo-inositol monophosphatase in spines and dendrites of cerebellar Purkinje neurons" Proc Natl Acad Sci U S A. 2005 Apr 19;102(16):5850-5 PMID:15809430 |
| Figure(s): | fig 2 |
| Annotation description: | Prior knowledge (PMID:12176979): IMPA1 (myo-inositol monophosphatase, IMPase) is an enzyme of the inositol-1,4,5-trisphosphate signaling cascade that is activated by the Ca2+-binding protein calbindin D28k (CB). Using FRAP technique the paper shows that the CB interacts with IMPase in dendritic spines of cerebellar Purkinje, implying that both proteins localise there. 09/10/2017 Pim - In in order to track CB translocaltion. this protein is of rat species ("Rat recombinant CB expressed ..."). |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Two-photon microscopy Fluorescence recovery after photobleaching (FRAP) |
| Annotator(s): | Alexandros Kanellopoulos (ORCID:0000-0002-2094-7491) Vittoria Mariano (ORCID:0000-0002-9848-0262) Achsel Tilmann (ORCID:0000-0002-1190-4481) Claudia Bagni (ORCID:0000-0002-4419-210X) |
| Lab: | Department of Fundamental Neurosciences, University of Lausanne, CH-1006 Lausanne, Switzerland; Dept Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy |
| SynGO annotation ID: | 1624 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |