Annotated protein:Septin-11. Gene symbol: SEPTIN11. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: B3GNI6
antibody wiki:
SynGO gene info:SynGO data @ SEPTIN11
Ontology domain:Cellular Component
SynGO term:postsynapse (GO:0098794)
Synapse type(s):cerebellum, glutamatergic
Annotated paper:Li X, et al. "Septin 11 is present in GABAergic synapses and plays a functional role in the cytoarchitecture of neurons and GABAergic synaptic connectivity" J Biol Chem. 2009 Jun 19;284(25):17253-17265 PMID:19380581
Figure(s):Fig1, Fig3 and Fig4
Annotation description:Fig1: Septin 11 migrates with the "type II" PSD fraction in cellular fractionation experiments that is also positive for gephyrin, but negative for PSD-95, suggesting these are GABAergic PSDs. This is verified by confocal microscopy in Fig3, where colocalization of septin 11 with GAD terminals is observed (54±4%), more then with vGlut1 synapses (25±2%; numbers from text p17257). Similar numbers are found in cerebellum (Fig3O-S). This is further verified by 2 methods of immunoEM (pre- and post-embedding; Fig4) in the cerebellum where Septin 11 is found in the dendrite an spine neck of synapses (Fig4A-G and 4J-K), and in the spine and PSD-area of some type II symmetric synapses (Fig4H-I ). Labelling on was absent on the presynaptic side or in axons (text p17258).

Note: note that this localisation to glutamatergic synapses is a minority (25%) of the general localisation.
Evidence tracking, Biological System:Intact tissue
Cultured neurons
Evidence tracking, Protein Targeting:Antibody (detection)
Evidence tracking, Experiment Assay:Electron Microscopy
Confocal
Biochemical fractionation (generic)
Annotator(s):Jan van Weering (ORCID:0000-0001-5259-4945)
Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:1616
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology