| Annotated protein: | Neuronal acetylcholine receptor subunit alpha-7. Gene symbol: CHRNA7. Taxonomy: Macaca Mulatta (Rhesus Macaque). Uniprot ID: Q866A2 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CHRNA7 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of presynaptic membrane (GO:0099056) |
| Synapse type(s): | neocortex, acetylcholinergic |
| Annotated paper: | Yang Y, et al. "Nicotinic alpha7 receptors enhance NMDA cognitive circuits in dorsolateral prefrontal cortex" Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):12078-83 PMID:23818597 |
| Figure(s): | Fig.2 |
| Annotation description: | Literal: "Similar triads involved receptor-reactive spines receiving both a glutamatergic synapse and axon appositions from cholinergic terminals, which could also contain α7-nACh autoreceptors (Fig. 2E)." Note: - because ACh autoreceptors the synapse type info is set to cholinergic - antibodies and labeled akphaBtx were used for detection. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antagonist / agonist Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 1606 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |