| Annotated protein: | Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI-associated protein 2) (BAI1-associated protein 2) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) (Insulin receptor tyrosine kinase substrate protein p53). Gene symbol: BAIAP2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q6GMN2 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ BAIAP2 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of modification of postsynaptic actin cytoskeleton (GO:1905274) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Choi J, et al. "Regulation of dendritic spine morphogenesis by insulin receptor substrate 53, a downstream effector of Rac1 and Cdc42 small GTPases" J Neurosci. 2005 Jan 26;25(4):869-79 PMID:15673667 |
| Figure(s): | fig 6-9 |
| Annotation description: | 9/10/2017 Pim - BAIAP2 is shown to influence spine density via OE and shRNA KD. BAIAP2 is a known regulator of actin structure signaling via WAVE2. Actin remodelling is shown to be involved via the WAVE2 protein in Fig.9. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA Over-expression |
| Evidence tracking, Experiment Assay: | Microscopy (generic) |
| Annotator(s): | Alexandros Kanellopoulos (ORCID:0000-0002-2094-7491) Vittoria Mariano (ORCID:0000-0002-9848-0262) Achsel Tilmann (ORCID:0000-0002-1190-4481) Claudia Bagni (ORCID:0000-0002-4419-210X) |
| Lab: | Department of Fundamental Neurosciences, University of Lausanne, CH-1006 Lausanne, Switzerland; Dept Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy |
| Additional literature: | Cultured rat hippocampal neurons double stained with anti-IRSp58/53 and synaptophysin show IRSp53 presence at synapses (Fig 7). @ PMID:10460236 |
| SynGO annotation ID: | 1603 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |