| Annotated protein: | Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1). Gene symbol: ABI2. Taxonomy: Mus musculus (Mouse). Uniprot ID: P62484 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ABI2 |
| Ontology domain: | Biological Process |
| SynGO term: | postsynaptic actin cytoskeleton organization (GO:0098974) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Grove M, et al. "ABI2-deficient mice exhibit defective cell migration, aberrant dendritic spine morphogenesis, and deficits in learning and memory" Mol Cell Biol. 2004 Dec;24(24):10905-22 PMID:15572692 |
| Figure(s): | fig 9 |
| Annotation description: | Immunohistochemistry on primary neurons from P2 hippocampus (DIV14-DIV21) from wild-type or Abi2-/- mice shows localization of Abi2 at dendritic spines. Furthermore analysis of dendritic spines in pyramidal neurons of neocortexes and CA1 regions of the hippocampus shows that loss of Abi2 results in aberrant spine morphology and density. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Alexandros Kanellopoulos (ORCID:0000-0002-2094-7491) Vittoria Mariano (ORCID:0000-0002-9848-0262) Achsel Tilmann (ORCID:0000-0002-1190-4481) Claudia Bagni (ORCID:0000-0002-4419-210X) |
| Lab: | Department of Fundamental Neurosciences, University of Lausanne, CH-1006 Lausanne, Switzerland; Dept Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy |
| SynGO annotation ID: | 1602 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |