| Annotated protein: | Cadherin-1 (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3]. Gene symbol: CDH1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q9R0T4 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CDH1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | brain |
| Annotated paper: | Fu AK, et al. "APC(Cdh1) mediates EphA4-dependent downregulation of AMPA receptors in homeostatic plasticity" Nat Neurosci. 2011 Feb;14(2):181-9 PMID:21186356 |
| Figure(s): | Fig. 5d |
| Annotation description: | The authors found that Cdh1 is concentrated in the detergent-resistant post-synaptic fractions of adult rat brain, which suggests that there is a tight association between APC and postsynaptic proteins (Fig. 5d). 28/8/2017 Pim - Functional data shows that APC/Cdh1 mediates ubituitination of AMPARs, and "Reduction of synaptic strength by ephrin-A1 or chronic treatment of bicuculline depends on APCCdh1-dependent proteasome degradation pathway" This is functional evidendce that Cdh1 is indeed localizated in the postsynapse. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Western blot Biochemical fractionation (generic) |
| Annotator(s): | Alexandros Kanellopoulos (ORCID:0000-0002-2094-7491) Vittoria Mariano (ORCID:0000-0002-9848-0262) Achsel Tilmann (ORCID:0000-0002-1190-4481) Claudia Bagni (ORCID:0000-0002-4419-210X) |
| Lab: | Department of Fundamental Neurosciences, University of Lausanne, CH-1006 Lausanne, Switzerland; Dept Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy |
| SynGO annotation ID: | 1599 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |