| Annotated protein: | Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (dC stretch-binding protein) (CSBP). Gene symbol: HNRNPK. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P61980 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ HNRNPK |
| Ontology domain: | Biological Process |
| SynGO term: | modulation of chemical synaptic transmission (GO:0050804) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Folci A, et al. "Loss of hnRNP K impairs synaptic plasticity in hippocampal neurons" J Neurosci. 2014 Jul 2;34(27):9088-95 PMID:24990929 |
| Figure(s): | Fig. 1B,C,E, 3 |
| Annotation description: | The mEPSC frequency is reduced upon hnRNP K silencing, indicating reduced pre-synaptic transmission. Note that the dendritic length, the number of dentiric branches and the number of spines is also affected. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA |
| Evidence tracking, Experiment Assay: | Electrophysiology (generic) |
| Annotator(s): | Alexandros Kanellopoulos (ORCID:0000-0002-2094-7491) Vittoria Mariano (ORCID:0000-0002-9848-0262) Achsel Tilmann (ORCID:0000-0002-1190-4481) Claudia Bagni (ORCID:0000-0002-4419-210X) |
| Lab: | Department of Fundamental Neurosciences, University of Lausanne, CH-1006 Lausanne, Switzerland; Dept Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy |
| Additional literature: | modulates dendritic branching and synaptogenesis (rat primary hippocampal neurons silenced with shRNA; branching is up, Bassoon-positive synapses are down) @ PMID:22102872 |
| SynGO annotation ID: | 1597 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |