| Annotated protein: | Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1). Gene symbol: HNRNPA2B1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: A7VJC2 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ HNRNPA2B1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic cytosol (GO:0099524) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Leal G, et al. "Neuronal activity induces synaptic delivery of hnRNP A2/B1 by a BDNF-dependent mechanism in cultured hippocampal neurons" PLoS One. 2014 Oct 6;9(10):e108175 PMID:25286195 |
| Figure(s): | Fig. 1, Fig. 3 |
| Annotation description: | Fig. 1 shows dendritic localisation in the vicinity of PSD-95-positive post-synapses. Fig. 3 (and 4) shows an increase of hnRNP A2/B1 in the vicinity of PSD-95 upon chemical stimulation of neuronal activity (primary hippocampal neurons, DIV 14-15) |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Wide-field fluorescence Western blot Biochemical fractionation (generic) |
| Annotator(s): | Alexandros Kanellopoulos (ORCID:0000-0002-2094-7491) Vittoria Mariano (ORCID:0000-0002-9848-0262) Achsel Tilmann (ORCID:0000-0002-1190-4481) Claudia Bagni (ORCID:0000-0002-4419-210X) |
| Lab: | Department of Fundamental Neurosciences, University of Lausanne, CH-1006 Lausanne, Switzerland; Dept Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy |
| Additional literature: | localised in neurites of primary neurons (rat hippocampus; unknown DIV: fig 7) and dendrites of rat hippocampus (molecular layer, fig 8) @ PMID:18305102 Figure 1 shows dendritic localisation in primary hippocampal neurons (DIV7-14). @ PMID:14523087 |
| SynGO annotation ID: | 1592 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |