| Annotated protein: | Metabotropic glutamate receptor 7 (mGluR7). Gene symbol: GRM7. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P35400-1 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GRM7 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of presynaptic active zone membrane (GO:0099059) |
| Synapse type(s): | hippocampus, glutamatergic hippocampus, GABAergic |
| Annotated paper: | Shigemoto R, et al. "Differential presynaptic localization of metabotropic glutamate receptor subtypes in the rat hippocampus" J Neurosci. 1997 Oct 1;17(19):7503-22 PMID:9295396 |
| Figure(s): | Fig. 12 and Table 1 |
| Annotation description: | An antibody against mGluR7a (G71) was used to localize mGluR7a in the rat hippocampus. Slices of rat brain were processed for immunogold EM and mGluR7a was found to localize to the presynape of perforant path CA1, CA3 and DG neurons and mossy fibers. Both symmetric and asymmetric synapses were observed 20/11/2017 Pim - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Ryan J. Farrell (ORCID:0000-0003-4022-8707) Ghazaleh Ashrafi (ORCID:0000-0001-7480-0826) Camila Pulido (ORCID:0000-0002-5648-066X) Jaime de Juan-Sanz (ORCID:0000-0002-1212-5623) Timothy Ryan (ORCID:0000-0003-2533-9548) |
| Lab: | Department of Biochemistry, Weill Cornell Medicine, New York, NY 10065, USA |
| SynGO annotation ID: | 1583 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |