| Annotated protein: | Pro-neuregulin-1, membrane-bound isoform (Pro-NRG1) [Cleaved into: Neuregulin-1 (Acetylcholine receptor-inducing activity) (ARIA) (Glial growth factor) (Heregulin) (HRG) (Neu differentiation factor) (Sensory and motor neuron-derived factor)]. Gene symbol: NRG1. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q6DR98 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ NRG1 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of presynapse assembly (GO:1905606) |
| Synapse type(s): | neocortex, GABAergic |
| Annotated paper: | Fazzari P, et al. "Control of cortical GABA circuitry development by Nrg1 and ErbB4 signalling" Nature. 2010 Apr 29;464(7293):1376-80 PMID:20393464 |
| Figure(s): | Fig. 2d-h, Fig. 3c-e, g, h |
| Annotation description: | Overexpression of type III (cysteine-rich domain (CRD-Nrg1); membrane-bound) form of Nrg1 increased number of GAD65-positive boutons contacting the soma of transfected hippocampal pyramidal neurons in vitro (Fig. 2d-h) and increased number of GAD65-positive boutons contacting the soma and axon initial segment of cortical pyramidal neurons in vivo. Thus, Nrg1 promotes the development of perisomatic and AIS GABAergic innervation of pyramidal neurons in vitro and in vivo. The loss of Neuregulin 1 receptor ErbB4 in cortical interneurons cell-autonomously impaired their ability to establish GABAergic synapses (Fig. 3c-e, g, h) , suggesting that Nrg1 (postsynaptic) and ErbB4 (presynaptic) signalling contributes to the establishment of GABAergic synapses onto pyramidal neurons in the cortex. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) Over-expression |
| Evidence tracking, Experiment Assay: | Confocal Field recordings |
| Annotator(s): | Tony Cijsouw (ORCID:0000-0003-0912-1514) Thomas Biederer (ORCID:0000-0002-3670-7863) |
| Lab: | Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA |
| SynGO annotation ID: | 1580 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |