| Annotated protein: | Rho guanine nucleotide exchange factor 9 (Collybistin) (Rac/Cdc42 guanine nucleotide exchange factor 9). Gene symbol: ARHGEF9. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q3UTH8 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ARHGEF9 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynaptic specialization assembly (GO:0099150) |
| Synapse type(s): | brain, GABAergic |
| Annotated paper: | Papadopoulos T, et al. "Impaired GABAergic transmission and altered hippocampal synaptic plasticity in collybistin-deficient mice" EMBO J. 2007 Sep 5;26(17):3888-99 PMID:17690689 |
| Figure(s): | Figs. 5-7 |
| Annotation description: | This paper describes the targeted disruption of the mouse Collybistin (CB) gene. CB-deficient mice display a region-specific loss of postsynaptic gephyrin and GABA A receptor clusters in the hippocampus and the basolateral amygdala. Significant impairment of inhibitory synapse function is shown by electrophysiology. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Microscopy (generic) Electrophysiology (generic) |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| Additional literature: | This publication supports the essential role of Collybistin in assembling inhibitory postsynapses, in this particular case induced by neuroligin-2 @ PMID:19755106 |
| SynGO annotation ID: | 156 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |