Annotated protein:	Myc box-dependent-interacting protein 1 (Amphiphysin II) (Amphiphysin-like protein) (Bridging integrator 1). Gene symbol: BIN1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: O08839
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SynGO gene info:	SynGO data @ BIN1
Ontology domain:	Biological Process
SynGO term:	synaptic vesicle endocytosis (GO:0048488)
Synapse type(s):	cerebellum
Annotated paper:	Wigge P, et al. "Amphiphysin heterodimers: potential role in clathrin-mediated endocytosis" Mol Biol Cell. 1997 Oct;8(10):2003-15 PMID:9348539
Figure(s):	Fig. 4, 8
Annotation description:	Amphiphysin 2/BIN1 forms heterodimers with Amphyphysin 1 and enhances clathrin-mediated endocytosis as observed in an heterologous transferrin uptake assay. The same paper describes the occurence of Amphyphysin 2 in presynaptic terminals. 13/12/2017 Pim - The function of BIN1_RAT/Amphyphysin II in the process of 'synaptic vesicle endocytosis (GO:0048488)' is not shown directly, but inferred from the authors from (1) the known role of Amph1 in this process, (2) the in vivo participation of Amph1 and Amph2 in the same protein complex, (3) the localization of Amph2 on the membrane of SVs and (4) the role of Amph2 in CDE in a heterologous system. I allow this inference w/o a IC structure.
Evidence tracking, Biological System:	Non-neuronal tissue
Evidence tracking, Protein Targeting:	Over-expression Antibody (detection)
Evidence tracking, Experiment Assay:	Wide-field fluorescence IP + WB/MSMS Y2H
Annotator(s):	Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414)
Lab:	Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany
SynGO annotation ID:	1496
Dataset release (version):	20231201
View annotation as GO-CAM model: