| Annotated protein: | Myc box-dependent-interacting protein 1 (Amphiphysin II) (Amphiphysin-like protein) (Bridging integrator 1). Gene symbol: BIN1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: O08839 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ BIN1 |
| Ontology domain: | Cellular Component |
| SynGO term: | extrinsic component of synaptic vesicle membrane (GO:0098850) |
| Synapse type(s): | cerebellum, glutamatergic |
| Annotated paper: | Wigge P, et al. "Amphiphysin heterodimers: potential role in clathrin-mediated endocytosis" Mol Biol Cell. 1997 Oct;8(10):2003-15 PMID:9348539 |
| Figure(s): | Fig. 3 F, G |
| Annotation description: | Fig. 3: Electron micrographs showing the ultrastructural localization of Amph2 in the rat cerebellum. The large mossy fiber terminals in the granule cell layer were found to be heavily stained with Amph2 reaction product (F), as were climbing fiber terminals in the molecular/ Purkinje cell layer (G). Within these structures, Amph2 staining was heavily concentrated on the outer layer of synaptic vesicles. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| SynGO annotation ID: | 1495 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |