Annotated protein:Amphiphysin. Gene symbol: AMPH. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q7TQF7
antibody wiki:
SynGO gene info:SynGO data @ AMPH
Ontology domain:Biological Process
SynGO term:synaptic vesicle endocytosis (GO:0048488)
Synapse type(s):cerebral cortex, glutamatergic
Annotated paper:Di Paolo G, et al. "Decreased synaptic vesicle recycling efficiency and cognitive deficits in amphiphysin 1 knockout mice" Neuron. 2002 Feb 28;33(5):789-804 PMID:11879655
Figure(s):Fig. 4,5,6
Annotation description:Synaptosomes of Amphiphysin knockout mice display reduced recycling of synaptic vesicles (Fig. 4 C,D). Cortical neurons in culture show also defects in synaptic vesicle dynamics as revealed by FM1-43 dye studies.

13/10/2017 Pim
- Endocytosis of SVs is measured by quanitfying uptake of FM1-43 upon stimulation of synaptosomes.
Evidence tracking, Biological System:Intact tissue
Cultured neurons
Evidence tracking, Protein Targeting:Genetic transformation (eg; knockout, knockin, mutations)
Evidence tracking, Experiment Assay:Confocal
Optical physiology
Annotator(s):Daniela Dieterich (ORCID:0000-0002-9880-1214)
Rainer Pielot (ORCID:0000-0002-9681-3318)
Karl-Heinz Smalla (ORCID:0000-0002-0269-0311)
Eckart Gundelfinger (ORCID:0000-0001-9377-7414)
Lab:Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany
SynGO annotation ID:1494
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology