| Annotated protein: | Synaptic vesicular amine transporter (Monoamine transporter) (Solute carrier family 18 member 2) (Vesicular amine transporter 2) (VAT2). Gene symbol: SLC18A2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q01827 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SLC18A2 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of neuronal dense core vesicle membrane (GO:0099066) |
| Synapse type(s): | brainstem |
| Annotated paper: | Nirenberg MJ, et al. "The vesicular monoamine transporter 2 is present in small synaptic vesicles and preferentially localizes to large dense core vesicles in rat solitary tract nuclei" Proc Natl Acad Sci U S A. 1995 Sep 12;92(19):8773-7 PMID:7568015 |
| Figure(s): | Fig. 2-4 |
| Annotation description: | In this study, Nirenberg et al. showed that VMAT2 is present in dense core vesicles and to a lesser extent in synaptic vesicles by electron microcopy. 22/11/2017 Pim - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Momchil Ninov (ORCID:0000-0002-0808-7003) Mahdokht Kohansalnodehi (ORCID:0000-0002-3898-5197) Reinhard Jahn (ORCID:0000-0003-1542-3498) |
| Lab: | Department of Neurobiology, Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany |
| SynGO annotation ID: | 1492 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |