| Annotated protein: | Calcium-binding protein 1 (CaBP1) (Caldendrin). Gene symbol: CABP1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: O88751 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CABP1 |
| Ontology domain: | Biological Process |
| SynGO term: | postsynapse to nucleus signaling pathway (GO:0099527) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Dieterich DC, et al. "Caldendrin-Jacob: a protein liaison that couples NMDA receptor signalling to the nucleus" PLoS Biol. 2008 Feb;6(2):e34 PMID:18303947 |
| Figure(s): | Fig. 5,8 |
| Annotation description: | Caldendrin and importin-alpha bind to jacob in a competitive manner (Fig. 5). Fig. 8: Caldendrin prevents shuttling of jacob to the nucleus. |
| Evidence tracking, Biological System: | Cultured neurons Non-neuronal tissue Cell-free system |
| Evidence tracking, Protein Targeting: | RNAi / shRNA Over-expression Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal Western blot IP + WB/MSMS Y2H |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| SynGO annotation ID: | 1491 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |