| Annotated protein: | 5-hydroxytryptamine receptor 7 (5-HT-7) (5-HT7) (5-HT-X) (GPRFO) (Serotonin receptor 7). Gene symbol: HTR7. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P32305 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ HTR7 |
| Ontology domain: | Biological Process |
| SynGO term: | presynaptic modulation of chemical synaptic transmission (GO:0099171) |
| Synapse type(s): | brainstem |
| Annotated paper: | Matott MP, et al. "Activation of 5-hyrdoxytryptamine 7 receptors within the rat nucleus tractus solitarii modulates synaptic properties" Brain Res. 2016 Mar 15;1635:12-26 PMID:26779891 |
| Figure(s): | Fig 2 |
| Annotation description: | In the presence of an agonist of 5-HT7, LP44, there were cells that increased or decreased EPSC amplitude from baseline, as well as cells that did not show an effect by LP44. Among these, the predominant effect of LP44 was to reduce EPSC amplitude during tractus solitarius (TS) stimulation (Fig 2A). The paired pulse ratio increased with increasing concentrations of LP 44. This indicates a presynaptic mechanism of modulation of transmission (Fig 2D). |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Ryan J. Farrell (ORCID:0000-0003-4022-8707) Ghazaleh Ashrafi (ORCID:0000-0001-7480-0826) Camila Pulido (ORCID:0000-0002-5648-066X) Jaime de Juan-Sanz (ORCID:0000-0002-1212-5623) Timothy Ryan (ORCID:0000-0003-2533-9548) |
| Lab: | Department of Biochemistry, Weill Cornell Medicine, New York, NY 10065, USA |
| SynGO annotation ID: | 1488 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |