| Annotated protein: | Spectrin beta chain. Gene symbol: SPTBN1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: G3V6S0 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SPTBN1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Sidenstein SC, et al. "Multicolour Multilevel STED nanoscopy of Actin/Spectrin Organization at Synapses" Sci Rep. 2016 May 25;6:26725 PMID:27220554 |
| Figure(s): | Fig3, Sup Fig5 |
| Annotation description: | Fig3 shows STED microscopy of betaII spectrin in combination with Homer (postsynaptic marker), Bassoon (presynaptic marker) and phalloidin, staining filamentous actin (mainly in spines). BetaII spectrin shows a periodic striped pattern in the dendrite that extends into the neck of spines and spine head. Supplementary Fig 5 shows an extended gallery of these spine images. betaII spectrin labeling does not seem to overlap with the active zone/PSD contact area indicated by the Homer and Bassoon staining. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Super resolution |
| Annotator(s): | Jan van Weering (ORCID:0000-0001-5259-4945) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 1479 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |