| Annotated protein: | Plasma membrane calcium-transporting ATPase 2 (PMCA2) (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 2) (Plasma membrane calcium pump isoform 2). Gene symbol: ATP2B2. Taxonomy: Homo sapiens (Human). Uniprot ID: Q01814 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ATP2B2 |
| Ontology domain: | Biological Process |
| SynGO term: | ATPase-coupled calcium ion transmembrane transporter activity involved in regulation of postsynaptic cytosolic calcium levels (GO:1905059) |
| Synapse type(s): | brain, glutamatergic brain, GABAergic |
| Annotated paper: | Hilfiker H, et al. "Cloning and expression of isoform 2 of the human plasma membrane Ca2+ ATPase. Functional properties of the enzyme and its splicing products" J Biol Chem. 1994 Oct 21;269(42):26178-83 PMID:7929331 |
| Figure(s): | Fig. 5 |
| Annotation description: | The primary PMID shows regulation of human PMCA2 activity expressed in insect Sf9 cells, the inference shows the occurence of PMCA2 in the postsynaptic membrane in the cerebellar cortex. rule: NAS_MFCC-BP rationale: Protein has 'calcium-transporting ATPase activity (GO:0005388)' and is localized in the presynaptic membrane (show with high-resolution technique). The inference to term 'ATPase-coupled calcium ion transmembrane transporter activity involved in regulation of presynaptic cytosolic calcium levels (GO:1905056)' is trivial and non-controversial. Pinf_CC: [P11506] SynGO ID 86 (PMID:17183553, EM) |
| Evidence tracking, Biological System: | Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Optical physiology |
| Non-tracable Author Statement (NAS): | This annotation required some inference over additional information/literature, and is not solely based on observations made in the annotated paper by its original authors. |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| SynGO annotation ID: | 1476 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |