| Annotated protein: | Netrin receptor DCC (Tumor suppressor protein DCC). Gene symbol: DCC. Taxonomy: Mus musculus (Mouse). Uniprot ID: P70211 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ DCC |
| Ontology domain: | Biological Process |
| SynGO term: | postsynaptic modulation of chemical synaptic transmission (GO:0099170) |
| Synapse type(s): | Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Horn KE, et al. "DCC expression by neurons regulates synaptic plasticity in the adult brain" Cell Rep. 2013 Jan 31;3(1):173-85 PMID:23291093 |
| Figure(s): | Figure 5 |
| Annotation description: | Figure 5: Impaired LTP but Intact LTD in DCCf/f,cre+ Mice. Floxed DCC mice crossed to CamKII-Cre mice show impaired LTP at CA3-CA1 synapses. Figure 6: Enhancing NMDAR function either by decreasing extracellular levels of Mg2+ or by pharmacologically activating Src completely rescued LTP in DCCf/f,cre+ mice. Authors conclude that DCC activation of Src is required for the induction of NMDAR-dependent LTP. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Field recordings |
| Annotator(s): | Ruud Toonen (ORCID:0000-0002-9900-4233) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 1470 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |