| Annotated protein: | Netrin receptor DCC (Tumor suppressor protein DCC). Gene symbol: DCC. Taxonomy: Mus musculus (Mouse). Uniprot ID: P70211 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ DCC |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic density membrane (GO:0099061) |
| Synapse type(s): | Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Horn KE, et al. "DCC expression by neurons regulates synaptic plasticity in the adult brain" Cell Rep. 2013 Jan 31;3(1):173-85 PMID:23291093 |
| Figure(s): | Figure 1 |
| Annotation description: | Fig 1: immunoelectron microscopy revealed enrichment of DCC in PSDs in the CA1 stratum radiatum of adult rat brain (Figure 1C). These findings demonstrate that DCC is enriched at mature synapses in dendritic spines. 24/10/2017 Pim - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy Western blot Biochemical fractionation (generic) |
| Annotator(s): | Ruud Toonen (ORCID:0000-0002-9900-4233) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 1469 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |