| Annotated protein: | Synapsin-2 (Synapsin II). Gene symbol: SYN2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q64332 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SYN2 |
| Ontology domain: | Biological Process |
| SynGO term: | synaptic vesicle cycle (GO:0099504) |
| Synapse type(s): | Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Rosahl TW, et al. "Essential functions of synapsins I and II in synaptic vesicle regulation" Nature. 1995 Jun 8;375(6531):488-93 PMID:7777057 |
| Figure(s): | Fig 2 |
| Annotation description: | Synapsin-II and Syn-I/II double knockouts, but not synapsin-I knockouts, exhibit decreased post-tetanic potentiation and severe synaptic depression upon repetitive stimulation. The phenotype of the synapsin knockouts could be explained either by deficient recruitment of synaptic vesicles to the active zone, or by impaired maturation of vesicles at the active zone. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Field recordings |
| Annotator(s): | Ruud Toonen (ORCID:0000-0002-9900-4233) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | synapsin IIa was the only isoform that could rescue the synaptic depression phenotype of the synapsin I,II and III triple knock-out mice. Synapsin IIa controls the size of the vesicular reserve pool in glutamatergic synapses @ PMID:18945891 |
| SynGO annotation ID: | 1467 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |