| Annotated protein: | Glutamate receptor ionotropic, NMDA 2B (GluN2B) (Glutamate [NMDA] receptor subunit epsilon-2) (N-methyl D-aspartate receptor subtype 2B) (NMDAR2B) (NR2B). Gene symbol: GRIN2B. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q00960 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GRIN2B |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic density membrane (GO:0099061) |
| Synapse type(s): | Mossy fiber synapse (DG->CA3) |
| Annotated paper: | Berg LK, et al. "Pre- and postsynaptic localization of NMDA receptor subunits at hippocampal mossy fibre synapses" Neuroscience. 2013 Jan 29;230:139-50 PMID:23159309 |
| Figure(s): | fig.2G, Fig.4 |
| Annotation description: | Localisation of NMDR subunits with immunogold EM. 8/9/2017 Pim - Fig.4 show pre and postsynaptic localization in mossy fiber synapses. - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Niels Cornelisse (ORCID:0000-0001-9425-2935) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 1462 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |