| Annotated protein: | Glycine receptor subunit alpha-3. Gene symbol: GLRA3. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q91XP5 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GLRA3 |
| Ontology domain: | Biological Process |
| SynGO term: | presynaptic modulation of chemical synaptic transmission (GO:0099171) |
| Synapse type(s): | brainstem, glycinergic |
| Annotated paper: | Kono Y, et al. "Presynaptic facilitation of glycinergic mIPSC is reduced in mice lacking alpha3 glycine receptor subunits" Neuroscience. 2016 Apr 21;320:1-7 PMID:26851771 |
| Figure(s): | Fig. 2B |
| Annotation description: | Reduced facilitation by forskolin of mIPSC-frequency in GLRA3 KO mice. 8/9/2017 Pim - Important to note here is that the basal glycinergic transmission (amplitude) in not negatively affected in KO animals. There are even larger mIPSC-amplitude in Glra3 -/- mice at P15-21. This shows that the GLRA3 is not present in the postsynapse mediating the postsynaptic currents. In contrast, forscolin is shown affect IPSC freq (increased SV release) via GLRA3. - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Niels Cornelisse (ORCID:0000-0001-9425-2935) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 1460 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |