| Annotated protein: | 5-hydroxytryptamine receptor 3A (5-HT3-A) (5-HT3A) (5-hydroxytryptamine receptor 3) (5-HT-3) (5-HT3R) (Serotonin receptor 3A) (Serotonin-gated ion channel receptor). Gene symbol: HTR3A. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P35563 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ HTR3A |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic membrane (GO:0099055) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Miquel MC, et al. "Differential subcellular localization of the 5-HT3-As receptor subunit in the rat central nervous system" Eur J Neurosci. 2002 Feb;15(3):449-57 PMID:11876772 |
| Figure(s): | fig.3E |
| Annotation description: | Immuno EM of 5-HT3A receptor 8/9/2017 Pim - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. - literal: "A dendritic spine with a dense immunolabelling at the level of a synaptic differentiation illustrates the typical postsynaptic ultrastructural distribution of immunostaining within the pyramidal cell layer (CA1) of the hippocampus (E)" |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Niels Cornelisse (ORCID:0000-0001-9425-2935) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 1458 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |