| Annotated protein: | Calcium-activated potassium channel subunit alpha-1 (BK channel) (BKCA alpha) (Calcium-activated potassium channel, subfamily M subunit alpha-1) (K(VCA)alpha) (KCa1.1) (Maxi K channel) (MaxiK) (Slo-alpha) (Slo1) (Slowpoke homolog) (Slo homolog). Gene symbol: KCNMA1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q62976 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ KCNMA1 |
| Ontology domain: | Biological Process |
| SynGO term: | ligand-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099507) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Hu H, et al. "Presynaptic Ca2+-activated K+ channels in glutamatergic hippocampal terminals and their role in spike repolarization and regulation of transmitter release" J Neurosci. 2001 Dec 15;21(24):9585-97 PMID:11739569 |
| Figure(s): | fig. 3A,B |
| Annotation description: | WC recording of effect of blocking BK channel on AP. 22/11/2017 Pim - The BL channel is channel activated by voltage and by intracellular calcium: " Whole-cell, intracellular, and field-potential recordings from CA1 pyramidal cells showed that the presynaptic BK channels are activated by calcium influx and can contribute to repolarization of the presynaptic action potential (AP) and negative feedback control of Ca2+ influx and transmitter release. " I have selected term ligand-gated ion channel ... where I considered Ca as the ligand. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Niels Cornelisse (ORCID:0000-0001-9425-2935) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 1446 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |