Annotated protein:Intersectin-1 (EH domain and SH3 domain regulator of endocytosis 1). Gene symbol: ITSN1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q9WVE9-1
antibody wiki:
SynGO gene info:SynGO data @ ITSN1
Ontology domain:Cellular Component
SynGO term:postsynaptic actin cytoskeleton (GO:0098871)
Synapse type(s):hippocampus, glutamatergic
Annotated paper:Thomas S, et al. "Intersectin regulates dendritic spine development and somatodendritic endocytosis but not synaptic vesicle recycling in hippocampal neurons" J Biol Chem. 2009 May 1;284(18):12410-9 PMID:19258322
Figure(s):fig 7
Annotation description:In fig 7, the authors show that intersection 1-long isoform co-localizes with actin in the post-synapse. intersectin 1-l is a known actin binding protein.
Evidence tracking, Biological System:Cultured neurons
Evidence tracking, Protein Targeting:Antibody (detection)
Evidence tracking, Experiment Assay:Confocal
Annotator(s):Peter McPherson (ORCID:0000-0001-7806-5662)
Lab:Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada
Additional literature:Intersectin-l is a GEF for Cdc42. In vitro, intersectin-l stimulates the formation of branched actin filaments by activating Cdc42 with subsequent downstream activation of N-WASP. @ PMID:11584276
SynGO annotation ID:1442
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology