| Annotated protein: | Spectrin beta chain. Gene symbol: SPTBN2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q68FG2 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SPTBN2 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic spectrin-associated cytoskeleton (GO:0099189) |
| Synapse type(s): | hippocampus cerebellum |
| Annotated paper: | Efimova N, et al. "betaIII Spectrin Is Necessary for Formation of the Constricted Neck of Dendritic Spines and Regulation of Synaptic Activity in Neurons" J Neurosci. 2017 Jul 5;37(27):6442-6459 PMID:28576936 |
| Figure(s): | Fig 2, 3 |
| Annotation description: | Figure3C shows immuno-gold localisation of betaIII spectrin, the gold particles accumulate at the spine neck and dendrite. Gold particles are never observed in proximity of the PSD, their average distance to the postsynaptic membrane is 416±260 nm (p6448). |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy Confocal |
| Annotator(s): | Jan van Weering (ORCID:0000-0001-5259-4945) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 1440 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |