| Annotated protein: | Phospholipid phosphatase-related protein type 4 (Brain-specific phosphatidic acid phosphatase-like protein 1) (Inactive 2-lysophosphatidate phosphatase PLPPR4) (Lipid phosphate phosphatase-related protein type 4) (Plasticity-related gene 1 protein) (PRG-1). Gene symbol: PLPPR4. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q7TME0 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PLPPR4 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic density membrane (GO:0099061) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Trimbuch T, et al. "Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling" Cell. 2009 Sep 18;138(6):1222-35 PMID:19766573 |
| Figure(s): | Fig. 1 |
| Annotation description: | Immuno staining of PRG-1 in synapses 21/11/2017 Pim - Literal: "...labeling exclusively at postsynaptic structures of asymmetric synapses of CA1 pyramidal cells and silver-enhanced immunogold signal of PRG-1 bordering the synaptic cleft (Figure 1D)." - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chose. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy Confocal Western blot Biochemical fractionation (generic) |
| Annotator(s): | Niels Cornelisse (ORCID:0000-0001-9425-2935) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | PGR-1 (gene PLPPR4) characterization @ PMID:12730698 |
| SynGO annotation ID: | 1412 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |