Annotated protein:Glutamate receptor ionotropic, NMDA 3B (GluN3B) (N-methyl-D-aspartate receptor subtype 3B) (NMDAR3B) (NR3B). Gene symbol: GRIN3B. Taxonomy: Homo sapiens (Human). Uniprot ID: O60391
antibody wiki:
SynGO gene info:SynGO data @ GRIN3B
Ontology domain:Biological Process
SynGO term:ligand-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099507)
Annotated paper:McClymont DW, et al. "Open-channel blockade is less effective on GluN3B than GluN3A subunit-containing NMDA receptors" Eur J Pharmacol. 2012 Jul 5;686(1-3):22-31 PMID:22564863
Figure(s):fig. 2A
Annotation description:Expression and electrophysiological measurements of GLUN3B in Xenopus Oocytes.

rule: NAS_MFCC-BP
rationale:
Protein has ligand-gated ion channel receptor activity and is localized in the presynaptic membrane (shown with high-resolution technique). The inference to term 'ligand-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099507)' is trivial and non-controversial.
Pinf_CC:
[Q8VHN2] SyNGO ID 1388 (PMID:23159309, EM)
Evidence tracking, Biological System:Non-neuronal tissue
Evidence tracking, Protein Targeting:Over-expression
Evidence tracking, Experiment Assay:Whole-cell patch clamp
Non-tracable Author Statement (NAS):This annotation required some inference over additional information/literature, and is not solely based on observations made in the annotated paper by its original authors.
Annotator(s):Niels Cornelisse (ORCID:0000-0001-9425-2935)
Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:1410
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology