Annotated protein: | Glutamate receptor ionotropic, NMDA 3B (GluN3B) (N-methyl-D-aspartate receptor subtype 3B) (NMDAR3B) (NR3B). Gene symbol: GRIN3B. Taxonomy: Homo sapiens (Human). Uniprot ID: O60391 |
antibody wiki: | |
SynGO gene info: | SynGO data @ GRIN3B |
Ontology domain: | Biological Process |
SynGO term: | ligand-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099507) |
Annotated paper: | McClymont DW, et al. "Open-channel blockade is less effective on GluN3B than GluN3A subunit-containing NMDA receptors" Eur J Pharmacol. 2012 Jul 5;686(1-3):22-31 PMID:22564863 |
Figure(s): | fig. 2A |
Annotation description: | Expression and electrophysiological measurements of GLUN3B in Xenopus Oocytes. rule: NAS_MFCC-BP rationale: Protein has ligand-gated ion channel receptor activity and is localized in the presynaptic membrane (shown with high-resolution technique). The inference to term 'ligand-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099507)' is trivial and non-controversial. Pinf_CC: [Q8VHN2] SyNGO ID 1388 (PMID:23159309, EM) |
Evidence tracking, Biological System: | Non-neuronal tissue |
Evidence tracking, Protein Targeting: | Over-expression |
Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
Non-tracable Author Statement (NAS): | This annotation required some inference over additional information/literature, and is not solely based on observations made in the annotated paper by its original authors. |
Annotator(s): | Niels Cornelisse (ORCID:0000-0001-9425-2935) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
SynGO annotation ID: | 1410 |
Dataset release (version): | 20231201 |
View annotation as GO-CAM model: |