| Annotated protein: | Huntingtin (Huntington disease protein homolog) (HD protein homolog) [Cleaved into: Huntingtin, myristoylated N-terminal fragment]. Gene symbol: HTT. Taxonomy: Mus musculus (Mouse). Uniprot ID: P42859 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ HTT |
| Ontology domain: | Biological Process |
| SynGO term: | postsynapse to nucleus signaling pathway (GO:0099527) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Marcora E, et al. "The Huntington's disease mutation impairs Huntingtin's role in the transport of NF-kappaB from the synapse to the nucleus" Hum Mol Genet. 2010 Nov 15;19(22):4373-84 PMID:20739295 |
| Figure(s): | Fig 6, Fig 7 |
| Annotation description: | Authors investigate whether Htt plays a role in transporting NF-kB from the postsynaptic compartment to the nucleus based on the fact that Htt interacts preferable with the active form of NF-kB. They performed photo activation experiments in primary hippocampal cultures of control and conditional htt knockout mice and observed that when htt was missing the half-life of NF-kB movement was double as compared to control mice. This data was in agreement with the quantification of NF-kB levels in the nucleus fraction prepared from control and knockout mice, which showed significantly lower levels in the absence of htt. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) RNAi / shRNA Antibody (detection) |
| Evidence tracking, Experiment Assay: | Two-photon microscopy Western blot Biochemical fractionation (generic) |
| Annotator(s): | Maria Andres-Alonso (ORCID:0000-0002-1585-539X) Michael Kreutz (ORCID:0000-0003-0575-6950) |
| Lab: | RG Neuroplasticity, Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany and Leibniz Group 'Dendritic Organelles and Synaptic Function', Center for Molecular Neurobiology, ZMNH, University MC, Hamburg-Eppendorf, Hamburg, 20251, Germany |
| SynGO annotation ID: | 1406 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |