Annotated protein:Syntaxin-binding protein 5 (Lethal(2) giant larvae protein homolog 3) (Tomosyn-1). Gene symbol: STXBP5. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8K400
antibody wiki:
SynGO gene info:SynGO data @ STXBP5
Ontology domain:Cellular Component
SynGO term:presynapse (GO:0098793)
Synapse type(s):hippocampus
Annotated paper:Geerts CJ, et al. "Tomosyn associates with secretory vesicles in neurons through its N- and C-terminal domains" PLoS One. 2017 Jul 26;12(7):e0180912 PMID:28746398
Figure(s):fig 2N
Annotation description:immuno-EM shows accumulation of the endogenous protein and expressed tomosyn-1 (which was shown to colocalize with endogenous at the LM level), iin presynaptic terminals
Evidence tracking, Biological System:Cultured neurons
Evidence tracking, Protein Targeting:Antibody (detection)
Evidence tracking, Experiment Assay:Electron Microscopy
Annotator(s):Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:1394
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology