| Annotated protein: | Syntaxin-binding protein 5 (Lethal(2) giant larvae protein homolog 3) (Tomosyn-1). Gene symbol: STXBP5. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q9WU70 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ STXBP5 |
| Ontology domain: | Cellular Component |
| SynGO term: | presynapse (GO:0098793) |
| Synapse type(s): | superior cervical ganglion (SCG) |
| Annotated paper: | Baba T, et al. "PKA-catalyzed phosphorylation of tomosyn and its implication in Ca2+-dependent exocytosis of neurotransmitter" J Cell Biol. 2005 Sep 26;170(7):1113-25 PMID:16186257 |
| Figure(s): | fig 4b and Fig 3 |
| Annotation description: | specific staining (absent in null mice, see supportive PMID) shows overlap with presynaptic markers Basoon, SYnaptophysin and Syntaxin, but less so with PSD95 |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | fig 1C shows that antibody staining used in main annotation is specific for tomosyn 1 using western blotting on null mutant brain lysate. Fig 3 indicates that tomosyn modulates SNARE-complex formation, a process that occurs on the presynaptic side, which strengthens the conclusion that tomosyn is presynaptic. @ PMID:18936251 |
| SynGO annotation ID: | 1393 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |