| Annotated protein: | Lethal giant larvae homologue 2 domain-containing protein (Tomosyn isoform A). Gene symbol: TOM-1. Taxonomy: Caenorhabditis elegans (Worm). Uniprot ID: Q49HI3 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ STXBP5 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of presynaptic dense core vesicle exocytosis (GO:0099161) |
| Synapse type(s): | acetylcholinergic |
| Annotated paper: | Gracheva EO, et al. "Tomosyn negatively regulates CAPS-dependent peptide release at Caenorhabditis elegans synapses" J Neurosci. 2007 Sep 19;27(38):10176-84 PMID:17881523 |
| Figure(s): | fig 1-2 |
| Annotation description: | DCV accumulate in presynaptic terminals of null mutant worms and accumulation of released DCV-reporter in coelomocytes is reduced in null worms |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Electron Microscopy Microscopy (generic) |
| Annotator(s): | Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 1389 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |