| Annotated protein: | Lethal giant larvae homologue 2 domain-containing protein (Tomosyn isoform A). Gene symbol: TOM-1. Taxonomy: Caenorhabditis elegans (Worm). Uniprot ID: Q49HI3 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ STXBP5 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of synaptic vesicle docking (GO:0099148) |
| Synapse type(s): | GABAergic Neuro-muscular junction |
| Annotated paper: | Gracheva EO, et al. "Tomosyn inhibits synaptic vesicle priming in Caenorhabditis elegans" PLoS Biol. 2006 Jul;4(8):e261 PMID:16895441 |
| Figure(s): | fig 4 |
| Annotation description: | tomosyn is a negative regulator of synaptic vesicle docking. in null worms the number of vesicles contacting the membrane is increased |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 1383 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |