| Annotated protein: | Glutamate receptor ionotropic, NMDA 2D (GluN2D) (Glutamate [NMDA] receptor subunit epsilon-4) (N-methyl D-aspartate receptor subtype 2D) (NMDAR2D) (NR2D). Gene symbol: GRIN2D. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q62645 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GRIN2D |
| Ontology domain: | Biological Process |
| SynGO term: | ligand-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099507) |
| Annotated paper: | Bresink I, et al. "Effects of memantine on recombinant rat NMDA receptors expressed in HEK 293 cells" Br J Pharmacol. 1996 Sep;119(2):195-204 PMID:8886398 |
| Figure(s): | Fig. 3C |
| Annotation description: | Electrophysiological characterisation of NR2D subunit overexposed in HEK cells. rule: NAS_MFCC-BP rationale: Protein has ligand-gated ion channel receptor activity and is localized in the presynaptic membrane (shown with high-resolution technique). The inference to term 'ligand-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099507)' is trivial and non-controversial. Pinf_CC: [G1TPJ8] SyNGO ID 1379 (PMID:9174077, confocal) [Q62645] SyNGO ID 1387 (PMID:23159309, EM) |
| Evidence tracking, Biological System: | Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Non-tracable Author Statement (NAS): | This annotation required some inference over additional information/literature, and is not solely based on observations made in the annotated paper by its original authors. |
| Annotator(s): | Niels Cornelisse (ORCID:0000-0001-9425-2935) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 1380 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |