| Annotated protein: | non-specific serine/threonine protein kinase (EC 2.7.11.1). Gene symbol: PAK1. Taxonomy: Macaca Mulatta (Rhesus Macaque). Uniprot ID: F6XUP1 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PAK1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | hippocampus neocortex |
| Annotated paper: | Ong WY, et al. "Differential distribution of alpha and beta isoforms of p21-activated kinase in the monkey cerebral neocortex and hippocampus" Exp Brain Res. 2002 May;144(2):189-99 PMID:12012157 |
| Figure(s): | Fig4, Fig5 and Fig7 |
| Annotation description: | Fig4 and Fig5 show immunoreactivity in the dendrite and postsynaptic compartment of PAKalpha in hippocampus and neocortex. The labelling is not so prominent in proximity of the PSD. In Fig7 the localization of the ultrastructural label is quantified, less than 5% were located in presynaptic zones of axon terminals and 10% on the PSD itself. Approximately 60% of gold particles for both αPAK were present in a perisynaptic location the area within 45 nm from the dendritic cell membrane and 200 nm from the edge of the PSD. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Jan van Weering (ORCID:0000-0001-5259-4945) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 1377 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |