| Annotated protein: | ADP-ribosylation factor 1 (EC 3.6.5.2). Gene symbol: ARF1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P84079 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ARF1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic density (GO:0014069) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Rocca DL, et al. "The small GTPase Arf1 modulates Arp2/3-mediated actin polymerization via PICK1 to regulate synaptic plasticity" Neuron. 2013 Jul 24;79(2):293-307 PMID:23889934 |
| Figure(s): | Fig.1 |
| Annotation description: | Fig1E shows subcellular fractionation indicating Arf1 and PICK1 in synaptosomes and PSD fractions I and II, while synaptotagmin is abscent. The authors describe ARF1 and PICK1 are "loosly associated" with the PSD. p295 25/10/2017 Pim - A complex of ARF1/PICK1/AMPAR can be immunoprecipitated from neuronal extracts. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression Antibody (detection) |
| Evidence tracking, Experiment Assay: | Western blot Biochemical fractionation (generic) IP + WB/MSMS |
| Annotator(s): | Jan van Weering (ORCID:0000-0001-5259-4945) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 1375 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |