Annotated protein:	Eukaryotic translation initiation factor 4E-binding protein (4E-BP) (d4E-BP) (eIF4E-binding protein) (4E-binding protein Thor) (dThor). Gene symbol: THOR. Taxonomy: Drosophila melanogaster (Fruit fly). Uniprot ID: Q9XZ56
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SynGO gene info:	SynGO data @ EIF4EBP1
Ontology domain:	Biological Process
SynGO term:	regulation of translation at presynapse, modulating synaptic transmission (GO:0099577)
Synapse type(s):	glutamatergic Neuro-muscular junction
Annotated paper:	Mahoney RE, et al. "Insulin signaling controls neurotransmission via the 4eBP-dependent modification of the exocytotic machinery" Elife. 2016 Aug 15;5:e16807 PMID:27525480
Figure(s):	fig 2
Annotation description:	The figure show that Drosophila 4E-BP regulates synaptic properties of the NMJ; precisely, knockdown of 4eBP (Thor) in motor neuron reduced the presynaptic release of neurotransmitter. 2/10/2017 Pim - Fig.2 shows the involvement of a Insulin->Tor pathway that regulates SV release. In subsequence figures the authors shows that this is via a nuclear mechanism that reslts in translational regulation of Complexin. Moreover, the 4E-BP protein is a known translational regulator. Together this shows that the effect of tor on SV release is indirectly via regulation of translation.
Evidence tracking, Biological System:	Intact tissue
Evidence tracking, Protein Targeting:	Genetic transformation (eg; knockout, knockin, mutations)
Evidence tracking, Experiment Assay:	Electrophysiology (generic)
Annotator(s):	Alexandros Kanellopoulos (ORCID:0000-0002-2094-7491) Vittoria Mariano (ORCID:0000-0002-9848-0262) Achsel Tilmann (ORCID:0000-0002-1190-4481) Claudia Bagni (ORCID:0000-0002-4419-210X)
Lab:	Department of Fundamental Neurosciences, University of Lausanne, CH-1006 Lausanne, Switzerland; Dept Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy
SynGO annotation ID:	1370
Dataset release (version):	20231201
View annotation as GO-CAM model: