| Annotated protein: | Eukaryotic translation initiation factor 4E binding protein 2. Gene symbol: EIF4EBP2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q497A9 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ EIF4EBP2 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Tang SJ, et al. "A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus" Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):467-72 PMID:11756682 |
| Figure(s): | fig 3 |
| Annotation description: | The figure shows the synaptic co-localization of 4E-BP2 with synapse in hippocampal neurons (P2; 14 DIV), furthermore 4E-EBP2 colocalize with PSD-95, postsynaptic marker. 24/9/2017 Pim - LiteralL "t high magnification, the immunostaining signals for eIF-4E, 4E-BP1, and 4E-BP2 were seen to oppose and slightly overlap with the signals for synapsin-I (a presynaptic protein) staining, suggesting their localization on the postsynaptic side (see Fig. Fig.33 Ac, Af, and Ai Insets). In particular, 4E-BP2 seemed to be significantly enriched in the postsynaptic region with a lower signal evident in the dendritic shaft, when compared with eIF-4E and 4E-BP1. The mTOR-positive regions were observed in the dendritic shaft in a diffuse pattern that extended into synaptic regions (Fig. (Fig.33Al). Consistent with the notion of postsynaptic localization of these proteins, double labeling with PSD-95 showed the signals from eIF-4E, 4E-BP1, and mTOR at synaptic regions almost completely overlapped with PSD-95 signals (Fig. (Fig.33B)." |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Alexandros Kanellopoulos (ORCID:0000-0002-2094-7491) Vittoria Mariano (ORCID:0000-0002-9848-0262) Achsel Tilmann (ORCID:0000-0002-1190-4481) Claudia Bagni (ORCID:0000-0002-4419-210X) |
| Lab: | Department of Fundamental Neurosciences, University of Lausanne, CH-1006 Lausanne, Switzerland; Dept Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy |
| SynGO annotation ID: | 1369 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |